Advances in Biological Mass Spectrometry
Description:
Mass spectrometry (MS) is extraordinarily powerful and versatile for analysis of molecules, and has been extensively applied to a wide range of research fields, including chemistry, biology and biomedicine. Over the last several decades, it has been tremendously advanced for biomolecular analysis, especially for macromolecules. Modern MS techniques can be used to unambiguously identify biomolecules and accurately quantify them. For example, MS provides a unique opportunity for characterizing proteins, including protein modifications and dynamics, and protein interactions with DNA and other molecules. Aberrant protein expression and interactions often result in human diseases, such as cancer and neurodegenerative diseases. Innovative and emerging MS-based techniques can profoundly advance our analysis of biomolecules, leading to a better understanding of the molecular mechanisms of disease, the identification of potential drug targets, and the discovery of biomarkers for early disease detection. This symposium will cover the latest development of novel MS-based methods for biomolecular analysis, from new instrumentation, innovative method developments, to exciting biological applications, which will bring frontier knowledge of MS to a broad range of audience.
Organizer: Ronghu Wu - Georgia Institute of Technology
Biography: Dr. Ronghu Wu is an associate professor in the School of Chemistry and Biochemistry at Georgia Institute of Technology (GT). His group has worked on the development of mass spectrometry-based chemical and enzymatic methods for comprehensive analysis of protein modifications, especially glycosylation, and applying them for biomedical research. Glycosylation is one of the most common and important protein modifications in mammalian cells, and it regulates nearly every extracellular activity. Global analysis of protein glycosylation will advance our understanding of glycoprotein functions and disease mechanisms, leading to the identification of glycoproteins as effective biomarkers and drug targets. He is a recipient of several awards, including the GT Blanchard Assistant Professorship (2014), the NSF CAREER Award (2015), the American Society for Mass Spectrometry Research Award (2016), and the GT CoS Cullen-Peck Faculty Scholar Award (2019), and Vasser-Woolley Professorship (2021).
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Ronghu Wu - Georgia Institute of Technology
Ling Hao - George Washington University
Yansheng Liu - Yale University
Aleksandra Nita-Lazar - National Institute of Allergy and Infectious Diseases / NIH
Michael Washburn - University of Kansas Medical Center
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Effective Mass Spectrometry-Based Methods for Comprehensive Characterization of Surface Glycoproteins and Their Dynamics
Ronghu Wu - Georgia Institute of Technology
Analyzing protein post-translational diversity by data-independent acquisition mass spectrometry
Yansheng Liu - Yale University School of Medicine
Capturing Lysosomal Dynamics with Multifaceted Mass Spectrometric Strategies
Ling Hao - George Washington University
Macrophage signaling mechanisms: deciphering protein networks
Aleksandra Nita-Lazar - NIAID, NIH
Decoding the Diversity Within Human Chromatin Remodeling Protein Interaction Networks
Michael Washburn - University of Kansas Medical Center
Advances in Biological Mass Spectrometry
Description
Session Number: S30-00
Session Type: Symposium
Session Date: Wednesday 3/22/2023
Session Time: 8:30 AM - 11:45 AM
Room Number: 121A
Track: Bioanalytics & Life Sciences
Category: Bioanalytical, Genomics/Proteomics/-Omics, Liquid Chromatography/Mass Spectrometry
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