The Emergence of Super-resolution Photothermal Infrared Spectroscopy
Description:
This presentation will be given by 2023 Williams-Wright award recipient Dr. Craig Prater. The presentation will overview the development and applications of two super-resolution photothermal infrared imaging and spectroscopy techniques, atomic force microscope-based infrared (AFM-IR) and optical photothermal infrared (O-PTIR). In both techniques, a sample is illuminated by a tunable infrared laser to excite molecular vibrations in the sample. IR light absorbed by molecular bonds in the sample causes a temperature rise a resulting photothermal distortion in the sample. The AFM-IR technique uses the tip of an AFM to detect subtle thermal expansion in the sample resulting from IR absorption. The O-PTIR technique use an optical probe beam to detect the IR induced temperature rise due to both thermal expansion and temperature-dependent changes in the sample's index of refraction. In both cases super-resolution IR absorption spectra and chemical images can be obtained by measuring the photothermal distortion as a function of wavelength (for spectra) or sample position (for images). The O-PTIR technique has been adapted to support simultaneous and co-located Raman spectroscopy, as well as providing integration with fluorescence microscopy. This presentation will overview the history of both AFM-IR and O-PTIR development, discuss the associated measurement technologies, and highlight key applications that have emerged in research and industry. Applications that will be discussed will include super-resolution biospectroscopy on cells and tissue, polymer analysis, failure/defect analysis, microplastics identification, and applications in cultural heritage.
Speaker: Craig Prater - Photothermal Spectroscopy Corp
Craig has been a leader in scientific instrument development for >30 years. After PhD work in atomic force microscopy (AFM), Craig spent 15 years in R&D/leadership roles at Veeco Metrology (now Bruker). Craig co-developed many AFM technologies now widely used in research and industry. Joining Anasys Instruments in 2007 Craig worked to develop/commercialize AFM-IR, enabling nanoscale chemical imaging and spectroscopy. Spurred by rapid growth in AFM-IR adoption, Anasys was acquired by Bruker in 2018. Craig and partners co-founded Photothermal Spectroscopy Corp (PSC) to commercialize Optical Photothermal Infrared (O-PTIR), which achieves >10X better spatial resolution vs. conventional IR spectroscopy. Craig has co-authored >140 publications and patents with over 9600 citations. The Coblentz Society selected Craig for the 2023 Williams-Wright Award for an “industrial spectroscopist who has made significant contributions to the field of vibrational spectroscopy while working in industry.”
Co-Authors
The Emergence of Super-resolution Photothermal Infrared Spectroscopy
Category
2023 Call for Invited Abstracts
Description
Session Number: AW05-01
Session Type: Award Abstract
Session Date: Monday 3/20/2023
Session Time: 8:30 AM - 11:50 AM
Room Number: 124
Track: Bioanalytics & Life Sciences
Category: Life Sciences, Polymers/Plastics, Vibrational Spectroscopy
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