Secondary Ion Mass Spectrometry - Past and Future
Description:
Secondary ion mass spectrometry (SIMS) was first reported by J.J. Thompson over 100 years ago. The basic idea is to bombard a surface with energetic ions and detect the secondary sputtered ions via mass spectrometry. The first analytical applications to materials science were reported in the 1950's with the introduction of the ion microscope. In the early 1970's intact molecules desorbed from surfaces were observed, which opened the field to organic chemists and biologists. This application benefited greatly from the emergence of time-of-flight mass spectrometry, where all secondary ions could be detected simultaneously. During the next decade, the introduction of the liquid metal ion source was transformative, since it got the community thinking about imaging SIMS with lateral resolution less than 100 nm. Fragmentation of molecules continued to be problematic. The appearance of the Cameca ion microprobe utilized fragmentation to selectively observe isotopically labeled ions with a spatial resolution to 10 nm. This difficulty was mitigated by the emergence of cluster ion sources. These sources, such as Bi3 and C60, allowed bigger molecules to be desorbed without significant fragmentation since the kinetic energy per atom was divided amongst all the atoms in the cluster. Moreover, accumulation of chemical damage on the sample was minimized, allowing the primary ion beam to erode the sample. This modality allowed depth profiling of materials with a depth resolution of less than 10 nm. At this point, chemical imaging of single biological cells became a real possibility. Remarkably, after all this time, technical advances in the SIMS field continue unabated. The most recent trend is the development of giant gas cluster ion sources which reduce damage and extend the mass range even further. These cluster ions can be tuned chemically to enhance ionization probability, and hence sensitivity. The latest and greatest new directions are presented in this symposium.
Speaker: NICHOLAS WINOGRAD - Penn State University
Winograd is currently an Evan Pugh University Professor Emeritus at Penn State University. He received his PhD in Chemistry from Case Western Reserve University in 1970, and was on the faculty of Purdue University until 1979, when he moved to Penn State. Winograd spent his career developing fundamental and applied aspects of secondary ion mass spectrometry. Most recently, he has focused upon the use of giant gas cluster ion beams as 3-dimensional imaging probes for biological single cells and tissue. He received the American Chemical Society award in Analytical Chemistry in 2012. He is currently retired and living with his spouse Barbara Garrison in Spring Mills, PA and Naples, Fl.
Co-Authors
Secondary Ion Mass Spectrometry - Past and Future
Category
2023 Call for Invited Abstracts
Description
Session Number: Waters-01
Session Type: Award Abstract
Session Date: Monday 3/20/2023
Session Time: 1:30 PM - 4:50 PM
Room Number: 126A
Track: Bioanalytics & Life Sciences
Category: Bioanalytical, Mass Spectrometry, Modeling/Simulation
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